Chronic constriction injury induces aquaporin-2 expression in the dorsal root ganglia of rats
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چکیده
منابع مشابه
Chronic sciatic nerve compression induces fibrosis in dorsal root ganglia
In the present study, pathological alterations in neurons of the dorsal root ganglia (DRG) were investigated in a rat model of chronic sciatic nerve compression. The rat model of chronic sciatic nerve compression was established by placing a 1 cm Silastic tube around the right sciatic nerve. Histological examination was performed via Masson's trichrome staining. DRG injury was assessed using Fl...
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Introduction: Until recently, chronic nerve compression (CNC) injuries have been relatively understudied. Recent studies have shown that CNC injury induces Schwann cell proliferation and apoptosis with no morphologic evidence of axonal injury (1,2). Moreover, axons within the zone of injury undergo a sprouting response that is readily apparent by two weeks following injury. Early work has shown...
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Neuropathic pain was produced by chronic constriction injury of the sciatic nerve in rats. Behavioral tests showed that the thresholds for thermal and mechanical hyperalgesia were significantly reduced in neuropathic pain rats 3-28 days following model induction. The results of immunohistochemistry, western blot assays and reverse transcription-PCR showed that Nav1.7 protein and mRNA expression...
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The presence of microglia in dorsal root ganglia (DRG) has not been reported earlier. The dorsal root ganglia contain satellite glial cells (SGCs) and macrophages, which are considered to have infiltrated from the systemic blood. An attempt was made to investigate whether microglia as found in the central nervous system are also present in the dorsal root ganglia of untreated rats and following...
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The evidence of neurons generated ex novo in sensory ganglia of adult animals is still debated. In the present study, we investigated, using high resolution light microscopy and stereological analysis, the changes in the number of neurons in dorsal root ganglia after 30 days from a crush lesion of the rat brachial plexus terminal branches. Results showed, as expected, a relevant hypertrophy of ...
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ژورنال
عنوان ژورنال: Journal of Anatomy
سال: 2009
ISSN: 0021-8782,1469-7580
DOI: 10.1111/j.1469-7580.2009.01143.x